Structural Glycobiology Methods

A fundamental understanding of carbohydrate structure and function would not be possible without the proper analytical tools. The development of methods that provide researchers with innovative tools for probing deeper into the molecular nature of carbohydrate interactions is critical for continued progress in carbohydrate research. Glycotec has several projects aimed at expanding this glycoanalytical toolbox. These include glycoengineering approaches that exploit bacterial systems to generate complex carbohydrates by design, single molecule and single cell techniques that will enable a closer look at carbohydrate-guided processes at the cell surface, novel mass spectrometry methods that will facilitate discovery of carbohydrate-binding proteins, and new computational methods that will enable exploration into carbohydrate structure and function at the atomic scale.